Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829914 | 0.83 | HSD17B2 (0.51) | POLBALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL9830524 | 0.81 | POLB (0.63) | POLBALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL9829790 | 0.80 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1GAAKDM4E | |
| SCHEMBL9830759 | 0.79 | LMNA (0.47) | POLBALDH1A1KMT2AMEN1GAA | |
| SCHEMBL9829654 | 0.79 | KMT2A (0.45) | KCNK3ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL2900687 | 0.75 | KMT2A (0.65) | POLBKCNK3ALDH1A1KMT2AGAA | |
| SCHEMBL9829764 | 0.74 | MEN1 (0.45) | ALDH1A1KMT2AMEN1KDM4ETSHR | |
| SCHEMBL9829064 | 0.74 | ALDH1A1 (0.43) | POLBALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL9831799 | 0.73 | MAPT (0.49) | POLBKCNK3ALDH1A1KMT2AMEN1 | |
| SCHEMBL9831615 | 0.71 | TACR1 (0.57) | POLBALDH1A1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |