Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.33 |
| ▸ | F2R | P25116 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830529 | 0.92 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP4F2CYP4A11ALOX5LTA4H | |
| SCHEMBL10408046 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2CYP4F2CYP4A11ALOX5LTA4H | |
| SCHEMBL9829450 | 0.81 | NLRP3 (0.43) | SMN1; SMN2CYP4F2CYP4A11ALOX5LTA4H | |
| SCHEMBL9830765 | 0.79 | ALDH1A1 (0.39) | SMN1; SMN2CYP4F2CYP4A11PPARGMAPT | |
| SCHEMBL9831675 | 0.79 | ALDH1A1 (0.39) | SMN1; SMN2CYP4F2CYP4A11PPARGMAPT | |
| SCHEMBL9830282 | 0.77 | ALDH1A1 (0.42) | SMN1; SMN2PPARGTDP1MAPTTSHR | |
| SCHEMBL9833415 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP4F2CYP4A11ALOX5LTA4H | |
| SCHEMBL9831307 | 0.75 | PPARG (0.43) | SMN1; SMN2CYP4F2CYP4A11ALOX5LTA4H | |
| SCHEMBL9831449 | 0.75 | SMN1; SMN2 (0.61) | SMN1; SMN2CYP4F2CYP4A11ALOX5LTA4H | |
| SCHEMBL9831853 | 0.74 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP4F2CYP4A11ALOX5LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |