SCHEMBL9831052

SCHEMBL9831052

COc1nc(C)ccc1C=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.41
TRIM24 O15164 1/20 0.40
TYR P14679 1/20 0.40
TRIM33 Q9UPN9 1/20 0.40
APOBEC3A P31941 1/20 0.38
APOBEC3G Q9HC16 1/20 0.38
TSHR P16473 3/20 0.38
KDM4E B2RXH2 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
MAT2A P31153 1/20 0.37
ERN1 O75460 4/20 0.37
GAA P10253 1/20 0.37
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
CYP1A2 P05177 1/20 0.36
TLR2 O60603 1/20 0.36
TLR1 Q15399 1/20 0.36
TLR6 Q9Y2C9 1/20 0.36
CA1 P00915 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29952654 0.82 ERN1 (0.52) ALDH1A1TRIM24TYRTRIM33TSHR
SCHEMBL1534756 0.82 ERN1 (0.52) ALDH1A1TRIM24TYRTRIM33TSHR
SCHEMBL30023734 0.80 NCF1 (0.44) ALDH1A1TRIM24TYRTRIM33TSHR
SCHEMBL29392617 0.80 MERTK (0.43) ALDH1A1TRIM24TYRTRIM33TSHR
SCHEMBL30772448 0.80 ALDH1A1 (0.39) ALDH1A1TRIM24TYRTRIM33TSHR
SCHEMBL2415421 0.80 PRKDC (0.40) ALDH1A1TRIM24TYRTRIM33TSHR
SCHEMBL1266601 0.80 MERTK (0.43) ALDH1A1TRIM24TYRTRIM33TSHR
SCHEMBL5096718 0.79 ALDH1A1 (0.38) ALDH1A1TRIM24TYRTRIM33TSHR
SCHEMBL29955945 0.78 CYP1A2 (0.41) ALDH1A1TSHRKDM4ETDP1ERN1
SCHEMBL1599165 0.78 CYP1A2 (0.41) ALDH1A1TSHRKDM4ETDP1ERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
EP-3190103-A1 INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION Rijksuniversiteit Groningen (NL) 2017-07-12 EP disclosed
EP-0161632-B1 PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES Roche Diagnostics GmbH (DE) 1991-04-10 EP disclosed
US-4963686-A INTERMEDIATES FOR INOTROPIC AGENTS BOEHRINGER MANNHEIM GMBH (DE) 1990-10-16 US disclosed
EP-0161632-A2 Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates Roche Diagnostics GmbH (DE) 1985-11-21 EP disclosed