Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29392617 | 1.00 | MERTK (0.43) | MERTKCRHBPCRHR2ALDH1A1NFE2L2 | |
| SCHEMBL30023734 | 0.81 | NCF1 (0.44) | ALDH1A1GAATRIM24TYRTRIM33 | |
| SCHEMBL17559335 | 0.80 | ALDH1A1 (0.56) | CRHBPCRHR2ALDH1A1GAAHPGD | |
| SCHEMBL9831052 | 0.80 | ALDH1A1 (0.41) | ALDH1A1GAASMN1; SMN2TRIM24TYR | |
| SCHEMBL29952654 | 0.78 | ERN1 (0.52) | ALDH1A1HPGDSMN1; SMN2TRIM24TYR | |
| SCHEMBL1534756 | 0.78 | ERN1 (0.52) | ALDH1A1HPGDSMN1; SMN2TRIM24TYR | |
| SCHEMBL30433024 | 0.77 | PDCD1LG2 (0.58) | — | |
| SCHEMBL21497019 | 0.77 | PDCD1LG2 (0.58) | — | |
| SCHEMBL2415421 | 0.77 | PRKDC (0.40) | ALDH1A1GAATRIM24TYRTRIM33 | |
| SCHEMBL30772448 | 0.77 | ALDH1A1 (0.39) | ALDH1A1GAATRIM24TYRTRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 378 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118702774-A | Preparation method and application of polypeptide coupling compound of targeted GPC-3 protein | 上海大学 | 2024-09-27 | — | — | CN | claimed |
| CN-117683021-A | PD-1/PD-L1 pathway targeting compound and nuclide marker, preparation and application thereof | 厦门大学 | 2024-03-12 | — | — | CN | claimed |
| EP-4746972-A1 | DEUTERATED PARP1 INHIBITOR COMPOUNDS | Duke Street Bio Limited (GB) | 2026-05-27 | — | — | EP | disclosed |
| CN-122079995-A | PD-1/PD-L1 and JAK double-target inhibitor, preparation method and application | — | 2026-05-26 | — | — | CN | disclosed |
| EP-4234030-B1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES INC (US) | 2026-04-08 | — | — | EP | disclosed |
| US-12590062-B2 | PD-1/PD-L1 inhibitors | GILEAD SCIENCES, INC. (US) | 2026-03-31 | — | — | US | disclosed |
| US-12583822-B2 | Benzylamine derivative, preparation method therefor and use thereof | ACADEMY OF MILITARY MEDICAL SCIENCES (CN) | 2026-03-24 | — | — | US | disclosed |
| EP-4045036-B1 | HETEROARYL-BIPHENYL AMIDES FOR THE TREATMENT OF PD-L1 DISEASES | CHEMOCENTRYX INC (US) | 2026-03-04 | — | — | EP | disclosed |
| US-20260042779-A1 | SYNTHESIS OF SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS AND SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND ANALOGUES THEREOF | ARBUTUS BIOPHARMA CORPORATION (CA) | 2026-02-12 | — | — | US | disclosed |
| EP-4045037-B1 | HETEROARYL-BIPHENYL AMINES FOR THE TREATMENT OF PD-L1 DISEASES | CHEMOCENTRYX INC (US) | 2026-01-28 | — | — | EP | disclosed |
| EP-4680226-A2 | ACYLSULFONAMIDE KAT6A INHIBITORS | Olema Pharmaceuticals, Inc. (US) | 2026-01-21 | — | — | EP | disclosed |
| EP-0565621-A1 | METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-10-20 | — | — | EP | disclosed |
| US-5254690-A | Alkoxymethylpyridine d-ring intermediates useful for the synthesis of camptpthecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-10-19 | — | — | US | disclosed |
| US-5247089-A | Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-09-21 | — | — | US | disclosed |
| US-5243050-A | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-09-07 | — | — | US | disclosed |
| US-5212317-A | Methods and intermediates for the assymmetric synthesis of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-05-18 | — | — | US | disclosed |
| US-5200524-A | Camptothecin intermediates and method of making same | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-04-06 | — | — | US | disclosed |
| US-5191082-A | Camptothecin intermediate and method of making camptothecin intermediates | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-03-02 | — | — | US | disclosed |
| US-5162532-A | INTERMEDIATES AND METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | NORTH CAROLINA STATE UNIVERSITY (US) | 1992-11-10 | — | — | US | disclosed |
| WO-1992011263-A1 | METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | NORTH CAROLINA STATE UNIVERSITY (US) | 1992-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260042779-A1 | SYNTHESIS OF SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS AND SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND ANALOGUES THEREOF | HAVCR2, NNMT, DOHH | MERTK 4085/4885CRHBP 4406/4885CRHR2 4231/4885 |
| US-12583822-B2 | Benzylamine derivative, preparation method therefor and use thereof | CD274, PDCD1, PDCD1LG2 | MERTK 4545/4885CRHBP 1800/4885CRHR2 317/4885 |
| US-12590062-B2 | PD-1/PD-L1 inhibitors | CD274, PDCD1LG2, PDCD1 | MERTK 3273/4885CRHBP 2922/4885CRHR2 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.