Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | VCP | P55072 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829808 | 0.88 | RAB9A (0.58) | LMNAMAPTRAB9ANPC1MEN1 | |
| SCHEMBL9832583 | 0.86 | LMNA (0.57) | LMNAALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL9830713 | 0.82 | HDAC6 (0.52) | MAPTRAB9ANPC1MAPK1GAA | |
| SCHEMBL9831892 | 0.81 | ABL1 (0.60) | LMNAALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL9829907 | 0.81 | LMNA (0.59) | LMNAALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL9829872 | 0.81 | RAB9A (0.62) | ALDH1A1MAPTSMN1; SMN2KDM4ERAB9A | |
| SCHEMBL9830542 | 0.80 | ALDH1A1 (0.66) | LMNAALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL9830531 | 0.80 | SMN1; SMN2 (0.47) | LMNAALDH1A1MAPTSMN1; SMN2PKM | |
| SCHEMBL25287793 | 0.79 | LMNA (0.90) | LMNAALDH1A1MAPTSMN1; SMN2PKM | |
| SCHEMBL9831525 | 0.79 | NPC1 (0.60) | LMNAALDH1A1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321115-B1 | CARBOXAMIDE DERIVATIVES HAVING TETRAZOLE AND THIAZOLE RINGS AND THEIR USE | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4946855-A | ANTIALLERGIC | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1990-08-07 | — | — | US | disclosed |
| EP-0321115-A1 | Carboxamide derivatives having tetrazole and thiazole rings and their use | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1989-06-21 | — | — | EP | disclosed |