Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831732 | 0.93 | ALDH1A1 (0.40) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14156362 | 0.82 | TDP1 (0.43) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9831313 | 0.81 | TDP1 (0.49) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL9829450 | 0.79 | NLRP3 (0.43) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5465593 | 0.78 | TDP1 (0.56) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL9830898 | 0.78 | ALDH1A1 (0.55) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9833033 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9833231 | 0.78 | PPARG (0.46) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL9831403 | 0.77 | SMN1; SMN2 (0.41) | ALDH1A1KDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL9831443 | 0.74 | PPARG (0.50) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |