Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832183 | 0.71 | NOS3 (0.36) | HRH3 | |
| SCHEMBL10407364 | 0.70 | CHRM5 (0.43) | HRH3CHRM5ADRA2COPRM1OPRL1 | |
| SCHEMBL4513010 | 0.68 | KDM4E (0.47) | CHRM5ADRA2CPKMCHRM2CHRM4 | |
| SCHEMBL27975973 | 0.66 | PKM (0.40) | HRH3CHRM5ADRA2CPKMACHE | |
| SCHEMBL15319538 | 0.63 | CHRM5 (0.47) | HRH3CHRM5ADRA2CACHECHRM2 | |
| SCHEMBL14401611 | 0.62 | HRH3 (0.43) | HRH3 | |
| SCHEMBL1307885 | 0.61 | CHRM5 (0.59) | CHRM5ADRA2COPRM1OPRL1ACHE | |
| SCHEMBL7384750 | 0.60 | KDM4E (0.52) | CHRM5PKMCHRM2CHRM4CHRM1 | |
| SCHEMBL29600183 | 0.59 | ALDH1A1 (0.58) | HRH3OPRM1OPRL1CHRM2CHRM4 | |
| SCHEMBL1307549 | 0.59 | CHRM5 (0.56) | CHRM5ADRA2COPRM1OPRL1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |