Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832327 | 0.93 | ALDH1A1 (0.50) | ALDH1A1POLBTSHRKDM4ETDP1 | |
| SCHEMBL9832835 | 0.92 | ALDH1A1 (0.47) | ALDH1A1TSHRKDM4EKMT2AMEN1 | |
| SCHEMBL9829941 | 0.85 | ALDH1A1 (0.42) | ALDH1A1KDM4EKMT2AMEN1HTT | |
| SCHEMBL9829851 | 0.85 | HSD17B10 (0.51) | ALDH1A1POLBTSHRKDM4EKMT2A | |
| SCHEMBL9831610 | 0.84 | ACHE (0.53) | SMN1; SMN2 | |
| SCHEMBL27790214 | 0.84 | ALDH1A1 (0.64) | ALDH1A1POLBTSHRKDM4ETDP1 | |
| SCHEMBL2224071 | 0.82 | ALDH1A1 (0.46) | ALDH1A1POLBTSHRKDM4ETDP1 | |
| SCHEMBL28854288 | 0.81 | LPAR1 (0.46) | ALDH1A1POLBTSHRKDM4ETDP1 | |
| SCHEMBL9833066 | 0.81 | ALDH1A1 (0.48) | ALDH1A1TSHRKMT2AHTTSMN1; SMN2 | |
| SCHEMBL1972974 | 0.81 | POLB (0.43) | ALDH1A1POLBTSHRKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |