Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833030 | 0.81 | KDM4E (0.41) | PGRALDH1A1 | |
| SCHEMBL9834972 | 0.78 | ATAD2 (0.50) | PGRATAD2 | |
| SCHEMBL10375567 | 0.76 | TNKS2 (0.45) | PGRALDH1A1MAPT | |
| SCHEMBL10566297 | 0.76 | — | — | |
| SCHEMBL9831260 | 0.75 | KDM4E (0.42) | ALDH1A1MAPT | |
| SCHEMBL9836473 | 0.74 | MAPK14 (0.33) | ATAD2 | |
| SCHEMBL9835813 | 0.72 | ATAD2 (0.31) | PGRATAD2 | |
| SCHEMBL28294093 | 0.70 | PGR (0.34) | PGRALDH1A1MAPT | |
| SCHEMBL9835008 | 0.69 | KDM4E (0.34) | ALDH1A1MAPT | |
| SCHEMBL9832475 | 0.67 | BRD4 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |