Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | LGMN | Q99538 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10407562 | 0.87 | ALDH1A1 (0.43) | ALDH1A1POLBMAPTKDM4ECASP3 | |
| SCHEMBL861735 | 0.85 | ALDH1A1 (0.45) | ALDH1A1POLBMAPTKDM4ECASP3 | |
| SCHEMBL9829380 | 0.85 | ALDH1A1 (0.45) | ALDH1A1POLBMAPTKDM4ELGMN | |
| SCHEMBL9831584 | 0.85 | LGMN (0.40) | ALDH1A1POLBMAPTKDM4ELGMN | |
| SCHEMBL9833258 | 0.85 | MAPT (0.55) | ALDH1A1MAPTKDM4ECASP3LGMN | |
| SCHEMBL9830725 | 0.84 | CA12 (0.46) | ALDH1A1POLBMAPTKDM4EHTT | |
| SCHEMBL9830218 | 0.84 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4EHTTGAA | |
| SCHEMBL9832087 | 0.83 | ALDH1A1 (0.43) | ALDH1A1POLBMAPTMEN1KMT2A | |
| SCHEMBL9832198 | 0.83 | CASP3 (0.43) | ALDH1A1POLBMAPTKDM4ECASP3 | |
| SCHEMBL9831685 | 0.83 | LMNA (0.46) | ALDH1A1POLBMAPTKDM4ECASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |