Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10407522 | 0.81 | AKR1C3 (0.48) | HSP90AA1ALDH1A3ALDH1A1MAPTLMNA | |
| SCHEMBL9831059 | 0.80 | ADRA1B (0.51) | ALDH1A1MAPTMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL10407412 | 0.77 | ALOX5 (0.50) | MKNK1MKNK2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL9832359 | 0.74 | BAZ2B (0.47) | HSP90AA1ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL9832904 | 0.74 | ADRB1 (0.51) | ALDH1A1MAPTLMNAMAPK1HTT | |
| SCHEMBL17543608 | 0.74 | ALDH1A1 (0.45) | ALDH1A3ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL17544147 | 0.74 | ALDH1A1 (0.45) | ALDH1A3ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL9830105 | 0.73 | HSP90AA1 (0.37) | HSP90AA1MKNK1MKNK2ALDH1A1SMN1; SMN2 | |
| SCHEMBL9830246 | 0.73 | HSP90AA1 (0.37) | HSP90AA1MKNK1MKNK2KMT2ANOTUM | |
| SCHEMBL10408072 | 0.73 | DRD3 (0.53) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |