Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 3/20 | 0.31 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833215 | 0.80 | ALDH1A1 (0.41) | ALDH1A1PGRKDM4E | |
| SCHEMBL9833705 | 0.79 | PGR (0.41) | ALDH1A1PGRMAPTTP53POLB | |
| SCHEMBL9832316 | 0.78 | ALDH1A1 (0.47) | ALDH1A1PGRMAPTTP53POLB | |
| SCHEMBL9834636 | 0.78 | ALDH1A1 (0.37) | ALDH1A1PGR | |
| SCHEMBL9834483 | 0.77 | IDO1 (0.35) | PGRMAPTTP53POLBNQO2 | |
| SCHEMBL9835978 | 0.75 | PGR (0.43) | PGRTP53POLBBRPF1CREBBP | |
| SCHEMBL9834640 | 0.72 | CHRNB2 (0.39) | ALDH1A1MAPTTP53POLBKDM4E | |
| SCHEMBL1455790 | 0.71 | IDO1 (0.58) | ALDH1A1MAPTKDM4EBRPF1CREBBP | |
| SCHEMBL9835029 | 0.70 | MAOB (0.39) | MAPTTP53BRPF1CREBBP | |
| SCHEMBL9833436 | 0.70 | BRPF1 (0.30) | BRPF1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |