Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.36 |
| ▸ | RAB9A | P51151 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | CASP1 | P29466 | 4/20 | 0.34 |
| ▸ | CASP7 | P55210 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833801 | 0.85 | KDM4E (0.38) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9832116 | 0.84 | KMT2A (0.31) | KDM4EALDH1A1KMT2A | |
| SCHEMBL9833448 | 0.75 | PTGS2 (0.32) | NPC1RAB9AKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL8113305 | 0.73 | HTR6 (0.36) | ALDH1A1USP2PTGS2 | |
| SCHEMBL8559896 | 0.70 | MAP4K4 (0.33) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9833779 | 0.70 | LMNA (0.34) | SMN1; SMN2 | |
| SCHEMBL9834624 | 0.68 | SMN1; SMN2 (0.50) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL9831757 | 0.67 | PKM (0.32) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9833178 | 0.67 | — | — | |
| SCHEMBL9832445 | 0.67 | SMN1; SMN2 (0.48) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0142811-A2 | Method of preparing 1,2,4-triazolo [1,5-a] - pyrimidine-2-sulfonyl chlorides | THE DOW CHEMICAL COMPANY (US) | 1985-05-29 | — | — | EP | claimed |
| EP-0142152-B1 | Novel substituted 1,2,4-triazolo- [1,5-a] pyrimidine-2-sulfonamides and compositions and methods of controlling undesired vegetation and suppressing the nitrification of ammonium nitrogen in soil | THE DOW CHEMICAL COMPANY (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4954163-A | PRE-AND POSTEMERGENCE HERBICIDES | THE DOW CHEMICAL COMPANY (US) | 1990-09-04 | — | — | US | disclosed |
| US-4886883-A | HERBICIDES | THE DOW CHEMICAL COMPANY (US) | 1989-12-12 | — | — | US | disclosed |
| EP-0330137-A1 | Intermediate compounds for the preparation of 1,2,4-triazolo [1,5-a]pyrimidine-2-sulfonamides | DowElanco (US) | 1989-08-30 | — | — | EP | disclosed |
| US-4818273-A | Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions containing them, and their utility as herbicides | THE DOW CHEMICAL COMPANY (US) | 1989-04-04 | — | — | US | disclosed |
| US-4755212-A | Novel substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides and compositions and method for inhibiting pollen formation in corn | THE DOW CHEMICAL COMPANY (US) | 1988-07-05 | — | — | US | disclosed |
| US-4741764-A | SUPPRESSION OF NITRIFICATION OF AMMONIUM NITROGEN IN THE SOIL | THE DOW CHEMICAL COMPANY (US) | 1988-05-03 | — | — | US | disclosed |
| US-4740233-A | Substituted 1,2,4-triazolo[1,5-a]-pyrimidine-2-sulfonamides and compositions and methods of controlling undesired vegetation and suppressing the nitrification of ammonium nitrogen in soil | THE DOW CHEMICAL COMPANY (US) | 1988-04-26 | — | — | US | disclosed |
| EP-0142152-A2 | Novel substituted 1,2,4-triazolo- [1,5-a] pyrimidine-2-sulfonamides and compositions and methods of controlling undesired vegetation and suppressing the nitrification of ammonium nitrogen in soil | THE DOW CHEMICAL COMPANY (US) | 1985-05-22 | — | — | EP | disclosed |