Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HBB | P68871 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835465 | 0.86 | BCHE (0.49) | MAPK1HBBHSD17B10LMNAKMT2A | |
| SCHEMBL9836501 | 0.81 | MAPK1 (0.52) | MAPK1HBBHSD17B10LMNAALDH1A1 | |
| SCHEMBL10886653 | 0.78 | ATM (0.55) | LMNAHPGDPOLB | |
| SCHEMBL10887271 | 0.76 | ATM (0.53) | HSD17B10LMNAALDH1A1KDM4EHPGD | |
| SCHEMBL9833975 | 0.74 | BCHE (0.39) | ALDH1A1HPGDGAAPOLBKMT2A | |
| SCHEMBL10431212 | 0.74 | BCHE (0.49) | MAPK1HBBHSD17B10LMNABCHE | |
| SCHEMBL10459751 | 0.73 | ACHE (0.51) | ALDH1A1KDM4EPOLBKMT2AFAAH | |
| SCHEMBL6991385 | 0.72 | HSD17B10 (0.65) | MAPK1HBBHSD17B10LMNAALDH1A1 | |
| SCHEMBL9837010 | 0.72 | HPGD (0.41) | LMNAKDM4EHPGDKMT2AFAAH | |
| SCHEMBL9835637 | 0.72 | KDM4E (0.59) | ALDH1A1KDM4EPOLBKMT2AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0238357-B1 | 1,2,4-TRIAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-29 | — | — | EP | disclosed |
| US-4898862-A | 1,2,4-triazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1990-02-06 | — | — | US | disclosed |
| EP-0238357-A2 | 1,2,4-Triazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1987-09-23 | — | — | EP | disclosed |