Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Clonazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 5/20 | 0.98 |
| ▸ | GABRA5 known ✓ | P31644 | 5/20 | 0.98 |
| ▸ | GABRA3 known ✓ | P34903 | 5/20 | 0.98 |
| ▸ | GABRA2 known ✓ | P47869 | 5/20 | 0.98 |
| ▸ | GABRB2 known ✓ | P47870 | 4/20 | 0.98 |
| ▸ | GABRG2 known ✓ | P18507 | 4/20 | 0.98 |
| ▸ | GABRB3 known ✓ | P28472 | 4/20 | 0.98 |
| ▸ | GABRP known ✓ | O00591 | 3/20 | 0.98 |
| ▸ | GABRD known ✓ | O14764 | 3/20 | 0.98 |
| ▸ | GABRB1 known ✓ | P18505 | 3/20 | 0.98 |
| ▸ | GABRA4 known ✓ | P48169 | 3/20 | 0.98 |
| ▸ | GABRE known ✓ | P78334 | 3/20 | 0.98 |
| ▸ | GABRA6 known ✓ | Q16445 | 3/20 | 0.98 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 3/20 | 0.98 |
| ▸ | GABRG3 known ✓ | Q99928 | 3/20 | 0.98 |
| ▸ | GABRQ known ✓ | Q9UN88 | 3/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clonazepam SCHEMBL31321724 | 1.00 | GABRA1 (0.98) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL29369721 | 0.99 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL13746712 | 0.99 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL5501860 | 0.99 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL38899 | 0.99 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL29743048 | 0.99 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL13747803 | 0.99 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL29361251 | 0.99 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL28390843 | 0.98 | GABRA1 (0.98) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL20771795 | 0.97 | GABRA1 (0.96) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230016-B1 | 6H-Isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-09-11 | — | — | EP | disclosed |
| EP-0230016-A1 | 6H-Isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-07-29 | — | — | EP | disclosed |
| US-4624955-A | 6H-isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines, method for their preparation and use as anxiolytic agents | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1986-11-25 | — | — | US | disclosed |