Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837594 | 0.85 | PDE3B (0.41) | MEN1KMT2AMAPTTP53HPGD | |
| SCHEMBL9836476 | 0.83 | TDP1 (0.48) | MAPTPDE3BPDE3APDE4APDE4B | |
| SCHEMBL9836932 | 0.83 | TSHR (0.43) | HPGDPDE3BPDE3APDE4APDE4B | |
| SCHEMBL9834628 | 0.82 | MAPT (0.43) | MAPTGAATP53HPGDPDE3B | |
| SCHEMBL9834522 | 0.81 | ALDH1A1 (0.42) | MEN1KMT2AMAPTGAATP53 | |
| SCHEMBL9835522 | 0.80 | HPGD (0.45) | MEN1KMT2AGAAHPGDPDE3B | |
| SCHEMBL9835976 | 0.79 | SMN1; SMN2 (0.47) | HPGDPDE3BPDE3APDE4APDE4B | |
| SCHEMBL9836412 | 0.79 | ALDH1A1 (0.51) | MAPTGAATP53HPGDSMN1; SMN2 | |
| SCHEMBL10474227 | 0.79 | KMT2A (0.52) | MEN1KMT2AMAPTGAATP53 | |
| SCHEMBL9835465 | 0.77 | BCHE (0.49) | MEN1KMT2ALMNATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0238357-B1 | 1,2,4-TRIAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-29 | — | — | EP | disclosed |
| US-4898862-A | 1,2,4-triazinone derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1990-02-06 | — | — | US | disclosed |
| EP-0238357-A2 | 1,2,4-Triazinone derivatives, their preparation and use | Sankyo Company Limited (JP) | 1987-09-23 | — | — | EP | disclosed |