Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.76 |
| ▸ | CTSS | P25774 | 1/20 | 0.76 |
| ▸ | CTSK | P43235 | 1/20 | 0.76 |
| ▸ | NMBR | P28336 | 8/20 | 0.75 |
| ▸ | BRS3 | P32247 | 2/20 | 0.67 |
| ▸ | TACR3 | P29371 | 1/20 | 0.67 |
| ▸ | TACR1 | P25103 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | ACE | P12821 | 1/20 | 0.64 |
| ▸ | CCKBR | P32239 | 2/20 | 0.63 |
| ▸ | BCHE | P06276 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834534 | 0.91 | CTSL (0.80) | CTSLCTSSCTSKNMBRTACR1 | |
| SCHEMBL7521907 | 0.90 | CTSL (0.67) | CTSLCTSSCTSKNMBRTACR3 | |
| SCHEMBL15145364 | 0.89 | CTSL (0.77) | CTSLCTSSCTSKNMBRTACR3 | |
| SCHEMBL15145404 | 0.89 | CTSL (0.77) | CTSLCTSSCTSKNMBRTACR3 | |
| SCHEMBL12371623 | 0.88 | NMBR (0.64) | CTSLCTSSCTSKNMBRBRS3 | |
| SCHEMBL18879584 | 0.87 | CTSL (0.74) | CTSLCTSSCTSKNMBRTACR3 | |
| SCHEMBL17884340 | 0.87 | CTSL (0.74) | CTSLCTSSCTSKNMBRTACR3 | |
| SCHEMBL30375072 | 0.87 | CTSL (0.80) | CTSLCTSSCTSKTACR3TACR1 | |
| SCHEMBL17807348 | 0.87 | CTSL (0.80) | CTSLCTSSCTSKNMBRTACR3 | |
| SCHEMBL8613263 | 0.87 | CCKBR (0.68) | CTSLCTSSCTSKNMBRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0442878-A4 | DERIVATIVES OF TRYPTOPHAN AS CCK ANTAGONISTS | — | 1991-10-23 | — | — | EP | disclosed |
| EP-0442878-A1 | DERIVATIVES OF TRYPTOPHAN AS CCK ANTAGONISTS | ABBOTT LABORATORIES (US) | 1991-08-28 | — | — | EP | disclosed |
| WO-1989010355-A1 | DERIVATIVES OF TRYPTOPHAN AS CCK ANTAGONISTS | ABBOTT LABORATORIES (US) | 1989-11-02 | — | — | WO | disclosed |
| EP-0336356-A2 | Derivatives of tryptophan as CCK antagonists | ABBOTT LABORATORIES (US) | 1989-10-11 | — | — | EP | disclosed |