Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 3/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834699 | 0.90 | ADAMTS5 (0.38) | PGRKDM4EATMNQO2ADAMTS5 | |
| SCHEMBL9833658 | 0.84 | FABP6 (0.43) | PGRALDH1A1 | |
| SCHEMBL9835234 | 0.84 | PGR (0.40) | PGRUSP2ALDH1A1ADAMTS5 | |
| SCHEMBL9834375 | 0.82 | PGR (0.36) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9834766 | 0.82 | KMT2A (0.48) | PGRKDM4E | |
| SCHEMBL9835004 | 0.82 | HPGD (0.40) | PGRALDH1A1 | |
| SCHEMBL9836082 | 0.82 | KDM4E (0.43) | PGRKDM4EATMALDH1A1 | |
| SCHEMBL9834606 | 0.81 | KDM4E (0.45) | PGRKDM4EALDH1A1 | |
| SCHEMBL9833008 | 0.80 | LMNA (0.44) | PGRNQO2 | |
| SCHEMBL10374413 | 0.80 | PGR (0.47) | PGRKDM4EPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |