Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.31 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836111 | 0.83 | HSD17B10 (0.47) | KDM4ELMNAHSD17B10PGRATM | |
| SCHEMBL9833658 | 0.82 | FABP6 (0.43) | PGRMEN1KMT2AALDH1A1AKT1 | |
| SCHEMBL9834590 | 0.82 | PGR (0.40) | KDM4EPGRATMALDH1A1 | |
| SCHEMBL9835234 | 0.82 | PGR (0.40) | PGRALDH1A1 | |
| SCHEMBL9834766 | 0.80 | KMT2A (0.48) | KDM4EPGRHTTKMT2A | |
| SCHEMBL9835004 | 0.80 | HPGD (0.40) | HSD17B10PGRMEN1HTTKMT2A | |
| SCHEMBL9834606 | 0.79 | KDM4E (0.45) | KDM4ELMNAHSD17B10PGRHTT | |
| SCHEMBL10374413 | 0.78 | PGR (0.47) | KDM4ELMNAHSD17B10PGRMEN1 | |
| SCHEMBL9833698 | 0.77 | PGR (0.36) | PGRATMMEN1HTTKMT2A | |
| SCHEMBL9833008 | 0.76 | LMNA (0.44) | LMNAPGRMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |