Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 9/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5001527 | 0.84 | CHRM1 (0.39) | CHRM1HTR1AMAPTNOTUM | |
| SCHEMBL4992293 | 0.83 | CHRM1 (0.38) | CHRM1DRD2KCNH2HTR1AHTR7 | |
| SCHEMBL5001522 | 0.76 | BMPR1B (0.43) | CHRM1HTR1AHTR7NOTUM | |
| SCHEMBL7476444 | 0.75 | DRD2 (0.63) | CHRM1DRD2DRD3CHRM2CHRM4 | |
| SCHEMBL5506028 | 0.74 | CHRM5 (0.48) | CHRM1CHRM5HTR1AMAPT | |
| SCHEMBL2008946 | 0.73 | AADAT (0.40) | CHRM1MAPTNOTUM | |
| SCHEMBL11839322 | 0.73 | KMT2A (0.64) | CHRM1DRD2DRD3CHRM2CHRM4 | |
| SCHEMBL4236105 | 0.72 | CHRM1 (0.53) | CHRM1DRD2DRD3CHRM2CHRM4 | |
| SCHEMBL6439411 | 0.72 | CHRM1 (0.70) | CHRM1DRD2DRD3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL9096810 | 0.71 | DRD2 (0.56) | CHRM1DRD2DRD3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |