Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 8/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.34 |
| ▸ | PDE4A | P27815 | 4/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | ACP1 | P24666 | 1/20 | 0.31 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834909 | 0.94 | ATAD2 (0.42) | ATAD2PGRPDK2PDK4PDE3B | |
| SCHEMBL9835356 | 0.82 | ATAD2 (0.46) | ATAD2PGRPDK2PDK4PDE3B | |
| SCHEMBL10662924 | 0.81 | ATAD2 (0.40) | ATAD2PGRPDK2PDK4PDE3B | |
| SCHEMBL10662906 | 0.78 | KAT2B (0.36) | ATAD2PGRPDE3BPDE3APDE4A | |
| SCHEMBL10668135 | 0.75 | ATAD2 (0.43) | ATAD2PGRPDK2PDK4PDE3B | |
| SCHEMBL9832960 | 0.75 | ATAD2 (0.38) | ATAD2PGRPDK2PDK4PDE3B | |
| SCHEMBL2492338 | 0.73 | PGR (0.42) | ATAD2PGRPDK2PDK4PDE3B | |
| SCHEMBL9835271 | 0.72 | ATAD2 (0.43) | ATAD2PGRPDK2PDK4PDE3B | |
| SCHEMBL9833546 | 0.72 | ATAD2 (0.38) | ATAD2PGRPDK2PDK4PDE3B | |
| SCHEMBL9834623 | 0.71 | ATAD2 (0.42) | ATAD2PGRPDK2PDK4PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |