SCHEMBL9835549

SCHEMBL9835549

COc1ccc(F)c(NC(=O)Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.54
SMN1; SMN2 Q16637 7/20 0.54
NPC1 O15118 6/20 0.54
MAPT P10636 5/20 0.54
TAS1R3 Q7RTX0 1/20 0.49
TAS1R1 Q7RTX1 1/20 0.49
TAS1R2 Q8TE23 1/20 0.49
HTT P42858 3/20 0.49
MEN1 O00255 4/20 0.48
KMT2A Q03164 4/20 0.48
GAA P10253 3/20 0.48
F10 P00742 1/20 0.47
PKM P14618 1/20 0.47
NFKB1 P19838 1/20 0.47
NFKB2 Q00653 1/20 0.47
RELA Q04206 1/20 0.47
POLB P06746 1/20 0.46
TP53 P04637 1/20 0.45
AKR1C3 P42330 1/20 0.44
AKR1C2 P52895 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21635517 0.85 RAB9A (0.55) RAB9ASMN1; SMN2NPC1MAPTTAS1R3
SCHEMBL9615374 0.85 RAB9A (0.58) RAB9ASMN1; SMN2NPC1MAPTTAS1R3
SCHEMBL166413 0.83 RAB9A (0.54) RAB9ASMN1; SMN2NPC1MAPTTAS1R3
SCHEMBL9836766 0.81 P2RX7 (0.58) RAB9ASMN1; SMN2NPC1MAPTMEN1
SCHEMBL28238289 0.81 KMT2A (0.53) RAB9ASMN1; SMN2NPC1MAPTHTT
SCHEMBL9836072 0.77 LMNA (0.55) RAB9ASMN1; SMN2NPC1MAPTHTT
SCHEMBL20505452 0.77 RAB9A (0.51) RAB9ASMN1; SMN2NPC1MAPTTAS1R3
SCHEMBL20505451 0.77 RAB9A (0.51) RAB9ASMN1; SMN2NPC1MAPTTAS1R3
SCHEMBL23074475 0.77 RAB9A (0.45) RAB9ASMN1; SMN2NPC1MAPTTAS1R3
SCHEMBL20560374 0.77 SMN1; SMN2 (0.51) SMN1; SMN2MAPTTAS1R3TAS1R1TAS1R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed