Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836532 | 0.88 | PDE3B (0.35) | KMOSMN1; SMN2PDE3BPDE3APDE4A | |
| SCHEMBL9836777 | 0.84 | KMO (0.44) | KMOALDH1A1SMN1; SMN2SIGMAR1MAPT | |
| SCHEMBL9835465 | 0.80 | BCHE (0.49) | NPC1NPSR1LMNAMEN1KMT2A | |
| SCHEMBL9835982 | 0.80 | KMO (0.41) | KMOALDH1A1MAPTHTTNPC1 | |
| SCHEMBL9836958 | 0.79 | PDE3B (0.37) | SMN1; SMN2NPC1PDE3BPDE3APDE4A | |
| SCHEMBL9835458 | 0.78 | PDE4A (0.40) | ALDH1A1MAPTPDE3BPDE3ALMNA | |
| SCHEMBL9836476 | 0.71 | TDP1 (0.48) | MAPTPDE3BPDE3APDE4APDE4B | |
| SCHEMBL10886653 | 0.70 | ATM (0.55) | HTTLMNA | |
| SCHEMBL9833986 | 0.69 | MAPK1 (0.53) | ALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL9833975 | 0.68 | BCHE (0.39) | ALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0238357-B1 | 1,2,4-TRIAZINONE DERIVATIVES, THEIR PREPARATION AND USE | Sankyo Company Limited (JP) | 1991-05-29 | — | — | EP | claimed |