Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835065 | 0.84 | PGR (0.36) | CHRNB2CHRNA4PGRPDE3BPDE3A | |
| SCHEMBL9834375 | 0.84 | PGR (0.36) | CHRNB2CHRNA4PGRPDE3BPDE3A | |
| SCHEMBL9833156 | 0.84 | FABP6 (0.46) | ALDH1A1TDP1PGRPDE3BPDE3A | |
| SCHEMBL9833849 | 0.82 | CHRNB2 (0.46) | CHRNB2CHRNA4MAPTPOLBHPGD | |
| SCHEMBL9834583 | 0.81 | HPGD (0.42) | MAPTPOLBHPGDKDM4EALDH1A1 | |
| SCHEMBL9835021 | 0.81 | CHRNB2 (0.43) | CHRNB2CHRNA4MAPTPOLBHPGD | |
| SCHEMBL9836111 | 0.81 | HSD17B10 (0.47) | HPGDKDM4EALDH1A1PGRPDE3B | |
| SCHEMBL9832544 | 0.80 | CHRNB2 (0.42) | CHRNB2CHRNA4MAPTPOLBHPGD | |
| SCHEMBL9833811 | 0.80 | KDM4E (0.48) | MAPTPOLBHPGDKDM4EALDH1A1 | |
| SCHEMBL9835242 | 0.79 | KMT2A (0.49) | MAPTPOLBKDM4ETDP1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |