Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835004 | 0.83 | HPGD (0.40) | HPGDSMN1; SMN2ALDH1A1OPRL1MAPT | |
| SCHEMBL9835975 | 0.81 | CHRNB2 (0.46) | HPGDSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL9833156 | 0.80 | FABP6 (0.46) | ALDH1A1MEN1KMT2APGRBMPR1B | |
| SCHEMBL9835065 | 0.80 | PGR (0.36) | PGRBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL9834375 | 0.80 | PGR (0.36) | PGRBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL9836111 | 0.78 | HSD17B10 (0.47) | HPGDALDH1A1PGRHSD17B10BMPR1B | |
| SCHEMBL10477754 | 0.77 | NPBWR1 (0.46) | HPGDSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL9833811 | 0.77 | KDM4E (0.48) | HPGDSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL10470299 | 0.76 | PDE3B (0.55) | HPGDSMN1; SMN2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL10566128 | 0.76 | PDE3B (0.34) | PGRBMPR1BBMPR1ATGFBR1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |