Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835975 | 0.82 | CHRNB2 (0.46) | CHRNB2CHRNA4MAPTPOLBKDM4E | |
| SCHEMBL9833439 | 0.77 | KDM4E (0.50) | MAPTPOLBKDM4EHPGDALDH1A1 | |
| SCHEMBL9834209 | 0.73 | MAPT (0.56) | MAPTPOLBKDM4EHPGDALDH1A1 | |
| SCHEMBL13041691 | 0.70 | ALDH1A1 (0.59) | CHRNB2CHRNA4MAPTPOLBKDM4E | |
| SCHEMBL9835021 | 0.70 | CHRNB2 (0.43) | CHRNB2CHRNA4MAPTPOLBKDM4E | |
| SCHEMBL9832544 | 0.69 | CHRNB2 (0.42) | CHRNB2CHRNA4MAPTPOLBKDM4E | |
| SCHEMBL12213872 | 0.68 | MAPT (0.68) | CHRNB2CHRNA4MAPTPOLBKDM4E | |
| SCHEMBL10666126 | 0.68 | ADAMTS5 (0.41) | CHRNB2CHRNA4MAPTPOLBKDM4E | |
| SCHEMBL9834932 | 0.68 | MAPT (0.40) | CHRNB2CHRNA4MAPTPOLBKDM4E | |
| SCHEMBL9834478 | 0.67 | CHRNB2 (0.40) | CHRNB2CHRNA4MAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |