Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 5/20 | 0.43 |
| ▸ | DHFR | P00374 | 5/20 | 0.40 |
| ▸ | ATIC | P31939 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837146 | 0.93 | GART (0.41) | GARTDHFRATICKDM4EALDH1A1 | |
| SCHEMBL9836207 | 0.87 | GART (0.44) | GARTDHFRATICKDM4EALDH1A1 | |
| SCHEMBL10519237 | 0.87 | GART (0.44) | GARTDHFRATICKDM4EALDH1A1 | |
| SCHEMBL10512971 | 0.87 | GART (0.58) | GARTDHFRATICKDM4EALDH1A1 | |
| SCHEMBL9836685 | 0.85 | GART (0.42) | GARTDHFRATICKDM4EALDH1A1 | |
| SCHEMBL9838445 | 0.76 | GART (0.72) | GARTDHFRATICTYMS | |
| SCHEMBL9838367 | 0.76 | DHFR (0.51) | GARTDHFRATICKDM4EALDH1A1 | |
| SCHEMBL9215054 | 0.74 | DHFR (0.37) | GARTDHFRATICKDM4EALDH1A1 | |
| SCHEMBL9534079 | 0.73 | GART (0.49) | GARTDHFRATICKDM4EALDH1A1 | |
| SCHEMBL9534086 | 0.73 | GART (0.49) | GARTDHFRATICKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255228-B1 | 4(3H)-OXO-5,6,7,8,-TETRAHYDROPYRIDO-(2,3-D)PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-05-02 | — | — | EP | disclosed |
| US-4831037-A | 4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-16 | — | — | US | disclosed |