Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | ACSL1 | P33121 | 2/20 | 0.54 |
| ▸ | ACSL6 | Q9UKU0 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 3/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834498 | 0.95 | ALDH1A1 (0.58) | ALDH1A1ACSL1ACSL6MEN1NPC1 | |
| SCHEMBL9836748 | 0.85 | KMT2A (0.57) | ALDH1A1ACSL1ACSL6MEN1NPC1 | |
| SCHEMBL9835332 | 0.83 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL9836782 | 0.82 | KMT2A (0.57) | ALDH1A1ACSL1ACSL6MEN1NPC1 | |
| SCHEMBL9836000 | 0.82 | NPC1 (0.53) | ALDH1A1ACSL1ACSL6MEN1NPC1 | |
| SCHEMBL1247012 | 0.79 | LMNA (0.82) | ALDH1A1ACSL1ACSL6MEN1NPC1 | |
| SCHEMBL9837487 | 0.79 | LMNA (0.72) | ALDH1A1ACSL1ACSL6NPC1KMT2A | |
| SCHEMBL9836675 | 0.79 | ALDH1A1 (0.53) | ALDH1A1ACSL1ACSL6MEN1NPC1 | |
| SCHEMBL9836568 | 0.79 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL9835666 | 0.79 | NPC1 (0.55) | ALDH1A1ACSL1ACSL6MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175376-B1 | XANTHONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-4816479-A | HYPOTENSIVE AGENTS, DIURETICS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1989-03-28 | — | — | US | disclosed |
| US-4661607-A | ANTIEDEMIC AGENTS, HYPOTENSIVE AGENTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1987-04-28 | — | — | US | disclosed |
| EP-0175376-A2 | Xanthone derivatives and process for producing the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1986-03-26 | — | — | EP | disclosed |