Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 7/20 | 0.72 |
| ▸ | ATIC | P31939 | 4/20 | 0.65 |
| ▸ | DHFR | P00374 | 3/20 | 0.57 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.55 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.54 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.54 |
| ▸ | TYMS | P04818 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836738 | 0.89 | GART (0.73) | GARTATICDHFRSOSTMTHFD2 | |
| SCHEMBL10524031 | 0.86 | GART (0.67) | GARTATICDHFRSOSTMTHFD2 | |
| SCHEMBL13418310 | 0.85 | SOST (0.72) | GARTATICDHFRSOSTMTHFD2 | |
| SCHEMBL258465 | 0.85 | SOST (0.72) | GARTATICDHFRSOSTMTHFD2 | |
| SCHEMBL3199681 | 0.85 | SOST (0.72) | GARTATICDHFRSOSTMTHFD2 | |
| SCHEMBL8061 | 0.85 | SOST (0.72) | GARTATICDHFRSOSTMTHFD2 | |
| SCHEMBL12704421 | 0.85 | SOST (0.72) | GARTATICDHFRSOSTMTHFD2 | |
| SCHEMBL8060 | 0.85 | SOST (0.72) | GARTATICDHFRSOSTMTHFD2 | |
| SCHEMBL29616598 | 0.85 | SOST (0.72) | GARTATICDHFRSOSTMTHFD2 | |
| Lometrexol SCHEMBL14469100 | 0.83 | GART (1.00) | GARTATICSOSTMTHFD2MTHFD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831037-A | 4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-16 | — | — | US | claimed |
| EP-0255228-B1 | 4(3H)-OXO-5,6,7,8,-TETRAHYDROPYRIDO-(2,3-D)PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-05-02 | — | — | EP | disclosed |
| US-4831037-A | 4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-16 | — | — | US | disclosed |
| US-4831037-A | 4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-16 | — | — | US | disclosed |