Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.63 |
| ▸ | ESR1 | P03372 | 2/20 | 0.63 |
| ▸ | KDM5A | P29375 | 1/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MGAM | O43451 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SI | P14410 | 1/20 | 0.51 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24727183 | 0.87 | ALDH1A1 (0.59) | MAOAESR2ESR1KDM5ACA12 | |
| SCHEMBL2316559 | 0.84 | MAOA (0.70) | MAOAESR2ESR1KDM5AKDM4E | |
| SCHEMBL9282004 | 0.80 | MAOA (0.63) | MAOAKDM5AKDM4EMAPTHSD17B10 | |
| SCHEMBL1983479 | 0.79 | MAOA (0.81) | MAOAESR2ESR1KDM5ACA12 | |
| SCHEMBL30468736 | 0.79 | MAOA (0.81) | MAOAESR2ESR1KDM5ACA12 | |
| SCHEMBL2299504 | 0.78 | MAOA (1.00) | MAOAESR2ESR1KDM5AKDM4E | |
| SCHEMBL29715739 | 0.78 | MAOA (1.00) | MAOAESR2ESR1KDM5AKDM4E | |
| SCHEMBL9837040 | 0.78 | LMNA (0.51) | MAOAESR2ESR1KDM5ALMNA | |
| SCHEMBL9837177 | 0.78 | PTPN1 (0.48) | MAOAESR2ESR1KDM5ALMNA | |
| SCHEMBL21327415 | 0.77 | MAOA (0.67) | MAOAESR2ESR1KDM5AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175376-B1 | XANTHONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-4816479-A | HYPOTENSIVE AGENTS, DIURETICS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1989-03-28 | — | — | US | disclosed |
| US-4661607-A | ANTIEDEMIC AGENTS, HYPOTENSIVE AGENTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1987-04-28 | — | — | US | disclosed |
| EP-0175376-A2 | Xanthone derivatives and process for producing the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1986-03-26 | — | — | EP | disclosed |