SCHEMBL9837181

SCHEMBL9837181

O=c1c2ccccc2oc2c(Cl)c(O)c(Cl)cc12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 8/20 0.58
TTR P02766 2/20 0.58
AHR P35869 1/20 0.55
PTGS2 P35354 1/20 0.55
KDM4E B2RXH2 2/20 0.50
CYP3A4 P08684 2/20 0.50
ALDH1A1 P00352 1/20 0.50
GLA P06280 1/20 0.50
MAPT P10636 1/20 0.50
HPGD P15428 1/20 0.50
PGAM1 P18669 1/20 0.50
CASP1 P29466 1/20 0.50
CASP7 P55210 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
HSD17B10 Q99714 1/20 0.50
KDM5A P29375 1/20 0.49
NMUR2 Q9GZQ4 1/20 0.47
MEN1 O00255 1/20 0.45
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8647132 0.84 ESR1 (0.49) MAOATTRAHRKDM4EALDH1A1
SCHEMBL9834774 0.79 TTR (0.49) MAOATTRPTGS2KDM4ECYP3A4
SCHEMBL9837415 0.79 MEN1 (0.51) MAOATTRAHRPTGS2KDM4E
SCHEMBL9836624 0.78 PTGS2 (0.71) MAOATTRPTGS2KDM4ECYP3A4
SCHEMBL7232063 0.76 PTGS2 (0.69) MAOATTRPTGS2KDM4ECYP3A4
SCHEMBL31174010 0.76 TTR (0.67) MAOATTRAHRPTGS2KDM4E
SCHEMBL5346099 0.76 TTR (0.67) MAOATTRAHRPTGS2KDM4E
SCHEMBL9837103 0.75 ALDH1A1 (0.58) TTRAHRKDM4EALDH1A1HSD17B10
SCHEMBL9836945 0.75 LMNA (0.65) MAOATTRAHRPTGS2KDM4E
SCHEMBL16477282 0.74 TTR (0.63) MAOATTRAHRPTGS2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9318712-B2 Xanthone compound and organic light-emitting device including the same CANON KABUSHIKI KAISHA (JP) 2016-04-19 US disclosed
US-9269911-B2 Organic light-emitting device CANON KABUSHIKI KAISHA (JP) 2016-02-23 US disclosed
US-20130214268-A1 XANTHONE COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME CANON KABUSHIKI KAISHA (JP) 2013-08-22 US disclosed
US-20130037791-A1 ORGANIC LIGHT-EMITTING DEVICE CANON KABUSHIKI KAISHA (JP) 2013-02-14 US disclosed
EP-0175376-B1 XANTHONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME Chugai Seiyaku Kabushiki Kaisha (JP) 1991-04-03 EP disclosed
US-4816479-A HYPOTENSIVE AGENTS, DIURETICS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1989-03-28 US disclosed
US-4661607-A ANTIEDEMIC AGENTS, HYPOTENSIVE AGENTS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1987-04-28 US disclosed
EP-0175376-A2 Xanthone derivatives and process for producing the same Chugai Seiyaku Kabushiki Kaisha (JP) 1986-03-26 EP disclosed