SCHEMBL9837199

SCHEMBL9837199

C=C(Cc1ccc(F)cc1)C(OC(=O)Nc1cc(Cl)cc(Cl)c1)C(=O)OCC

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KLK7 P49862 5/20 0.43
SMN1; SMN2 Q16637 3/20 0.40
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
KCNQ4 P56696 2/20 0.38
KCNQ3 O43525 1/20 0.38
KCNQ2 O43526 1/20 0.38
KCNQ5 Q9NR82 1/20 0.38
ALOX15 P16050 2/20 0.38
MAPT P10636 1/20 0.38
RXFP1 Q9HBX9 1/20 0.37
GAA P10253 1/20 0.37
HPGD P15428 2/20 0.37
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 2/20 0.37
MAOB P27338 1/20 0.36
CETP P11597 2/20 0.36
S1PR2 O95136 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10559825 0.87 KLK7 (0.43) KLK7SMN1; SMN2MEN1KMT2AALOX15
SCHEMBL9836787 0.84 MAPT (0.42) KLK7ALOX15MAPTHPGDALDH1A1
SCHEMBL9835869 0.79 KMT2A (0.43) KLK7MEN1KMT2AALOX15MAPT
SCHEMBL9837783 0.78 TSHR (0.41) SMN1; SMN2MEN1KMT2AALOX15MAPT
SCHEMBL9835245 0.76 MEN1 (0.46) SMN1; SMN2MEN1KMT2AALOX15MAPT
SCHEMBL27366044 0.73 KMT2A (0.48) SMN1; SMN2MEN1KMT2AKCNQ3KCNQ2
SCHEMBL9836991 0.70 MAPT (0.46) KLK7SMN1; SMN2MEN1KMT2AMAPT
SCHEMBL10950808 0.69 KDM4E (0.60) SMN1; SMN2MEN1KMT2AMAPTHPGD
SCHEMBL9835786 0.68 HPGD (0.43) SMN1; SMN2MEN1KMT2AALOX15MAPT
SCHEMBL27368860 0.68 MEN1 (0.39) SMN1; SMN2MEN1KMT2AALOX15MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed