SCHEMBL9835245

SCHEMBL9835245

C=C(c1ccc(F)cc1)C(OC(=O)Nc1cc(Cl)cc(Cl)c1)C(=O)OC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 7/20 0.46
KMT2A Q03164 7/20 0.46
MAOB P27338 1/20 0.41
HPGD P15428 2/20 0.40
KDM4E B2RXH2 2/20 0.40
ALOX15 P16050 1/20 0.40
ALDH1A1 P00352 2/20 0.38
MAPT P10636 4/20 0.38
HTT P42858 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
XBP1 P17861 1/20 0.38
RAB9A P51151 4/20 0.37
NPC1 O15118 2/20 0.37
POLB P06746 1/20 0.37
MAPK1 P28482 1/20 0.37
LMNA P02545 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
SENP6 Q9GZR1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27366044 0.88 KMT2A (0.48) MEN1KMT2AMAOBHPGDKDM4E
SCHEMBL9835786 0.81 HPGD (0.43) MEN1KMT2AHPGDALOX15ALDH1A1
SCHEMBL9837118 0.79 MAPT (0.45) MEN1KMT2AHPGDALOX15ALDH1A1
SCHEMBL27368858 0.79 HPGD (0.42) MEN1KMT2AMAOBHPGDKDM4E
SCHEMBL9836278 0.79 KMT2A (0.48) MEN1KMT2AHPGDKDM4EALOX15
SCHEMBL9837199 0.76 KLK7 (0.43) MEN1KMT2AMAOBHPGDKDM4E
SCHEMBL9835566 0.76 ALDH1A1 (0.44) MEN1KMT2AHPGDALDH1A1MAPT
SCHEMBL9837732 0.76 SMN1; SMN2 (0.43) MEN1KMT2AHPGDKDM4EALDH1A1
SCHEMBL9836787 0.75 MAPT (0.42) HPGDALOX15ALDH1A1MAPTRAB9A
SCHEMBL9834329 0.74 NPC1 (0.52) MEN1KMT2AHPGDKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed