Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 15/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834169 | 0.89 | SMYD3 (0.49) | SMYD3AHR | |
| SCHEMBL3255662 | 0.80 | SMYD3 (0.53) | SMYD3EPHX2AHR | |
| SCHEMBL3581228 | 0.78 | SMYD3 (0.55) | SMYD3EPHX2AHRHDAC3 | |
| SCHEMBL11461325 | 0.78 | AHR (0.66) | SMYD3EPHX2AHRHDAC3 | |
| SCHEMBL3569829 | 0.78 | SMYD3 (0.55) | SMYD3EPHX2AHRHDAC3 | |
| SCHEMBL11460719 | 0.77 | AHR (0.55) | SMYD3EPHX2AHRHDAC3 | |
| SCHEMBL16180358 | 0.77 | PDE3B (0.61) | SMYD3EPHX2AHRPDE3BPDE3A | |
| SCHEMBL9833998 | 0.77 | JAK3 (0.50) | SMYD3EPHX2AHR | |
| SCHEMBL688890 | 0.76 | TDP2 (0.61) | SMYD3EPHX2AHRPDE3BPDE3A | |
| SCHEMBL3575509 | 0.75 | SMYD3 (0.52) | SMYD3EPHX2AHRHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4791129-A | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4725616-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0208510-A2 | 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | PFIZER INC. (US) | 1987-01-14 | — | — | EP | disclosed |
| CN-86105309-A | Oxindole-3-carbonyl amines the compound that replaces as the 1-of anti-inflammatory and anodyne | — | 1987-01-14 | — | — | CN | disclosed |