Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.48 |
| ▸ | AHR | P35869 | 3/20 | 0.45 |
| ▸ | CMA1 | P23946 | 2/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 4/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837319 | 0.89 | SMYD3 (0.49) | SMYD3AHR | |
| SCHEMBL3573876 | 0.80 | SMYD3 (0.56) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL7679044 | 0.80 | SMYD3 (0.53) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL3573881 | 0.78 | SMYD3 (0.55) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL9836061 | 0.78 | SMYD3 (0.49) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL9836325 | 0.77 | CES2 (0.39) | SMYD3CRBNPKML3MBTL1CES2 | |
| SCHEMBL3581639 | 0.76 | TDP2 (0.55) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL3194345 | 0.76 | SMYD3 (0.58) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL29713338 | 0.76 | TDP2 (0.66) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL398818 | 0.76 | TDP2 (0.66) | SMYD3CRBNAHRCMA1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4791129-A | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4725616-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0208510-A2 | 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | PFIZER INC. (US) | 1987-01-14 | — | — | EP | disclosed |
| CN-86105309-A | Oxindole-3-carbonyl amines the compound that replaces as the 1-of anti-inflammatory and anodyne | — | 1987-01-14 | — | — | CN | disclosed |