Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835089 | 0.83 | ALOX5 (0.47) | ALDH1A1EPHX2L3MBTL1MEN1KMT2A | |
| SCHEMBL9508809 | 0.76 | MGLL (0.44) | MEN1KMT2A | |
| SCHEMBL14897950 | 0.76 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2A | |
| SCHEMBL9836108 | 0.73 | NPC1 (0.54) | NPC1RAB9AALDH1A1EPHX2ATM | |
| SCHEMBL14876048 | 0.73 | S1PR3 (0.39) | ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL14875922 | 0.73 | S1PR3 (0.39) | ALDH1A1MEN1KMT2A | |
| SCHEMBL4287111 | 0.72 | MAPK1 (0.59) | NPC1RAB9AALDH1A1EPHX2ATM | |
| SCHEMBL2436091 | 0.71 | MEN1 (0.42) | MEN1KMT2A | |
| SCHEMBL13889647 | 0.70 | NPC1 (0.60) | NPC1RAB9AALDH1A1EPHX2L3MBTL1 | |
| SCHEMBL9837743 | 0.70 | MEN1 (0.46) | NPC1RAB9AEPHX2L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200377-B1 | HYDROXAMATES | SQUIBB & SONS INC (US) | 1991-10-09 | — | — | EP | disclosed |
| EP-0200377-A2 | Hydroxamates | E.R. Squibb & Sons, Inc. (US) | 1986-11-05 | — | — | EP | disclosed |
| US-4604407-A | Hydroxamates | E. R. SQUIBB & SONS, INC. (US) | 1986-08-05 | — | — | US | disclosed |