SCHEMBL9837437

SCHEMBL9837437

CC=C(C)C(OC(=O)Nc1cc(OC(C)(C)C)c(Cl)cc1F)C(=O)OC

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
POLB P06746 2/20 0.33
ALDH1A1 P00352 2/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
MAPT P10636 2/20 0.33
TSHR P16473 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
TP53 P04637 1/20 0.33
DHODH Q02127 7/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
APEX1 P27695 1/20 0.32
RORC P51449 1/20 0.31
PYGL P06737 1/20 0.31
KMT2A Q03164 2/20 0.31
KDM4E B2RXH2 1/20 0.31
GAA P10253 1/20 0.31
MEN1 O00255 1/20 0.30
USP2 O75604 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8998088 0.88 LMNA (0.34) LMNANPSR1POLBALDH1A1NPC1
SCHEMBL8998090 0.88 LMNA (0.34) LMNANPSR1POLBALDH1A1NPC1
SCHEMBL9834362 0.88 LMNA (0.34) LMNANPSR1POLBALDH1A1NPC1
SCHEMBL9836339 0.87 DHODH (0.40) LMNANPSR1POLBALDH1A1NPC1
SCHEMBL9836639 0.86 DHODH (0.39) LMNANPSR1POLBALDH1A1NPC1
SCHEMBL9836189 0.85 DHODH (0.39) LMNANPSR1POLBALDH1A1NPC1
SCHEMBL9836734 0.83 LMNA (0.36) LMNANPSR1POLBALDH1A1NPC1
SCHEMBL9868327 0.81 ALDH1A1 (0.40) LMNANPSR1POLBALDH1A1NPC1
SCHEMBL8998049 0.79 ALDH1A1 (0.34) LMNANPSR1ALDH1A1NPC1RAB9A
SCHEMBL8998044 0.79 ALDH1A1 (0.34) LMNANPSR1ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed