SCHEMBL9834362

SCHEMBL9834362

C=C(C)C(OC(=O)Nc1cc(OC(C)(C)C)c(Cl)cc1F)C(=O)OC

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.34
MAPT P10636 3/20 0.34
NPSR1 Q6W5P4 2/20 0.34
POLB P06746 2/20 0.34
ALDH1A1 P00352 2/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
TSHR P16473 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
TP53 P04637 1/20 0.33
DHODH Q02127 1/20 0.33
SMN1; SMN2 Q16637 3/20 0.32
APEX1 P27695 1/20 0.32
RORC P51449 1/20 0.32
PYGL P06737 1/20 0.31
KMT2A Q03164 2/20 0.31
KDM4E B2RXH2 2/20 0.31
GAA P10253 1/20 0.31
MAPK1 P28482 1/20 0.31
MEN1 O00255 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9835450 0.90 NPSR1 (0.43) LMNAMAPTNPSR1POLBALDH1A1
SCHEMBL9837428 0.90 LMNA (0.37) LMNAMAPTNPSR1POLBALDH1A1
SCHEMBL9836734 0.89 LMNA (0.36) LMNAMAPTNPSR1POLBALDH1A1
SCHEMBL9837437 0.88 LMNA (0.33) LMNAMAPTNPSR1POLBALDH1A1
SCHEMBL8998058 0.88 LMNA (0.34) LMNAMAPTNPSR1POLBALDH1A1
SCHEMBL9427372 0.87 LMNA (0.34) LMNAMAPTNPSR1POLBALDH1A1
SCHEMBL9835444 0.87 RORC (0.39) LMNAMAPTNPSR1POLBALDH1A1
SCHEMBL8998045 0.83 SCN9A (0.42) TSHRRORC
SCHEMBL9835963 0.80 RORC (0.39) LMNAMAPTNPSR1POLBALDH1A1
SCHEMBL9837587 0.79 LMNA (0.47) LMNAMAPTNPSR1POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed