Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 8/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | TTR | P02766 | 3/20 | 0.51 |
| ▸ | KDM5A | P29375 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 4/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.47 |
| ▸ | ATP1A1 | P05023 | 2/20 | 0.44 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.44 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.44 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.44 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.44 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.44 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.44 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837184 | 0.85 | ESR1 (0.52) | MAOAEGFRKDM5APTGS2ESR1 | |
| SCHEMBL9836624 | 0.81 | PTGS2 (0.71) | MAOAEGFRTTRKDM5APTGS2 | |
| SCHEMBL9837036 | 0.81 | ATP1A1 (0.55) | MAOAEGFRTTRPTGS2ESR1 | |
| SCHEMBL9836052 | 0.79 | SRD5A1 (0.47) | MAOAEGFRTTRKDM5APTGS2 | |
| SCHEMBL15346134 | 0.78 | ATP1A1 (0.64) | MAOAPTGS2ESR1ESR2ATP1A1 | |
| SCHEMBL9835732 | 0.75 | TTR (0.48) | MAOATTR | |
| SCHEMBL29755034 | 0.74 | KDM4E (0.52) | MAOATTRKDM5APTGS2ESR1 | |
| SCHEMBL9836803 | 0.74 | TTR (0.54) | MAOATTRPTGS2ESR1ESR2 | |
| SCHEMBL149545 | 0.73 | MAOA (0.73) | MAOAEGFRKDM5APTGS2ATP1A1 | |
| SCHEMBL9834846 | 0.73 | AHR (0.54) | TTRPTGS2ESR1ESR2ATP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175376-B1 | XANTHONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-4816479-A | HYPOTENSIVE AGENTS, DIURETICS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1989-03-28 | — | — | US | disclosed |
| US-4661607-A | ANTIEDEMIC AGENTS, HYPOTENSIVE AGENTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1987-04-28 | — | — | US | disclosed |
| EP-0175376-A2 | Xanthone derivatives and process for producing the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1986-03-26 | — | — | EP | disclosed |