Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837387 | 0.80 | KIF11 (0.45) | MAPTPOLBKMT2ALMNAKIF11 | |
| SCHEMBL5078615 | 0.75 | MAPT (0.51) | MAPTPOLBNPSR1KMT2AKDM4E | |
| SCHEMBL2205707 | 0.75 | MAPT (0.51) | MAPTPOLBNPSR1KMT2AKDM4E | |
| SCHEMBL2205704 | 0.75 | MAPT (0.51) | MAPTPOLBNPSR1KMT2AKDM4E | |
| SCHEMBL29343549 | 0.73 | TDP1 (0.47) | MAPTPOLBNPSR1KMT2AKDM4E | |
| SCHEMBL9835582 | 0.72 | USP2 (0.39) | POLBL3MBTL1ALDH1A1LMNATP53 | |
| SCHEMBL4145986 | 0.72 | ALDH1A1 (0.50) | MAPTPOLBNPSR1KDM4ERAB9A | |
| SCHEMBL4145995 | 0.72 | ALDH1A1 (0.50) | MAPTPOLBNPSR1KDM4ERAB9A | |
| SCHEMBL30152652 | 0.72 | ALDH1A1 (0.50) | MAPTPOLBNPSR1KDM4ERAB9A | |
| SCHEMBL4145990 | 0.72 | ALDH1A1 (0.50) | MAPTPOLBNPSR1KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219308-B1 | 2-SUBSTITUTED QUINOLINES | MERCK FROSST CANADA INC. (CA) | 1991-10-23 | — | — | EP | disclosed |