Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836921 | 0.82 | MAPT (0.36) | MAPTNPC1GAAALDH1A1HPGD | |
| SCHEMBL31271045 | 0.76 | ALDH1A1 (0.47) | MAPTRAB9AGAAALDH1A1HPGD | |
| SCHEMBL10771693 | 0.75 | IKBKB (0.45) | MAPTIKBKBRAB9ANPC1GAA | |
| SCHEMBL19814919 | 0.73 | GAA (0.38) | MAPTRAB9AGAAALDH1A1HPGD | |
| SCHEMBL9040652 | 0.72 | HSD11B1 (0.37) | MAPTALDH1A1HPGDLMNAHTT | |
| SCHEMBL9838214 | 0.72 | DYRK1A (0.42) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL31484401 | 0.72 | SMN1; SMN2 (0.35) | MAPTRAB9AGAAALDH1A1HPGD | |
| SCHEMBL31484402 | 0.70 | NPC1 (0.34) | MAPTNPC1GAAALDH1A1HPGD | |
| SCHEMBL18357928 | 0.68 | CYP3A4 (0.46) | MAPTGAAALDH1A1ALOX15TDP1 | |
| SCHEMBL9837792 | 0.67 | CDK2 (0.37) | MAPTRAB9AGAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223420-B1 | CONDENSED IMIDAZOPYRIDINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1991-02-27 | — | — | EP | disclosed |
| US-4753951-A | ANTIDEPRESSANTS, ANXIOLYTICS | SHIONOGI & CO., LTD. (JP) | 1988-06-28 | — | — | US | disclosed |
| EP-0223420-A1 | Condensed imidazopyridine derivatives | SHIONOGI & CO., LTD. (JP) | 1987-05-27 | — | — | EP | disclosed |