Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 6/20 | 0.43 |
| ▸ | PNP | P00491 | 2/20 | 0.41 |
| ▸ | GART | P22102 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 2/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | ATIC | P31939 | 1/20 | 0.39 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10813052 | 0.78 | CYP1A2 (0.59) | CYP1A2KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL13916085 | 0.78 | CYP1A2 (0.51) | CYP1A2KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL10808383 | 0.77 | CYP1A2 (0.48) | CYP1A2KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL10809113 | 0.77 | GART (0.48) | CYP1A2KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL744451 | 0.74 | CYP1A2 (0.48) | CYP1A2KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL9838375 | 0.74 | KDM4E (0.51) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL6303945 | 0.72 | DHFR (0.48) | DHFR | |
| Hydrochloric Acid SCHEMBL10807714 | 0.71 | DHFR (0.47) | DHFR | |
| SCHEMBL13833239 | 0.70 | KDM4E (0.49) | CYP1A2KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL398501 | 0.70 | NOS1 (0.55) | KDM4EMEN1ALDH1A1MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255228-B1 | 4(3H)-OXO-5,6,7,8,-TETRAHYDROPYRIDO-(2,3-D)PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-05-02 | — | — | EP | disclosed |
| US-4833145-A | 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-23 | — | — | US | disclosed |
| US-4831037-A | 4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-16 | — | — | US | disclosed |
| EP-0255228-A1 | 4(3H)-Oxo-5,6,7,8,-Tetrahydropyrido-(2,3-d)Pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1988-02-03 | — | — | EP | disclosed |