SCHEMBL3199681

SCHEMBL3199681

Nc1nc2c(c(=O)[nH]1)N[C@H](CN(C=O)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)CN2

nearest known ligand 0.72

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SOST Q9BQB4 1/20 0.72
GART P22102 6/20 0.70
FPGS Q05932 2/20 0.64
DHFR P00374 3/20 0.59
ATIC P31939 4/20 0.55
TYMS P04818 1/20 0.55
MTHFD2 P13995 2/20 0.54
MTHFD1 P11586 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12704421 1.00 SOST (0.72) SOSTGARTFPGSDHFRATIC
SCHEMBL258465 1.00 SOST (0.72) SOSTGARTFPGSDHFRATIC
SCHEMBL8061 1.00 SOST (0.72) SOSTGARTFPGSDHFRATIC
SCHEMBL8060 1.00 SOST (0.72) SOSTGARTFPGSDHFRATIC
SCHEMBL29616598 1.00 SOST (0.72) SOSTGARTFPGSDHFRATIC
SCHEMBL13418310 1.00 SOST (0.72) SOSTGARTFPGSDHFRATIC
SCHEMBL5829838 0.96 SOST (0.66) SOSTGARTFPGSDHFRATIC
Tetrahydrofolate SCHEMBL18703989 0.94 SOST (0.82) SOSTGARTFPGSDHFRATIC
SCHEMBL11475679 0.93 SOST (0.62) SOSTGARTFPGSDHFRATIC
SCHEMBL8160135 0.93 SOST (0.71) SOSTGARTFPGSDHFRATIC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6808725-B2 FOOD ADDITIVE SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION 2004-10-26 US claimed
EP-1425978-A1 Food and vitamin preparations containing the natural isomer of reduced folates South Alabama Medical Science Foundation (US) 2004-06-09 EP claimed
EP-0877563-B1 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES UNIV SOUTH ALABAMA (US) 2004-03-31 EP claimed
US-20020176912-A1 Food and vitamin preparations containing the natural isomer of reduced folates SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION 2002-11-28 US claimed
US-20020150653-A1 Food and vitamin preparations containing the natural isomer of reduced folates SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION 2002-10-17 US claimed
US-20010046533-A1 METHOD FOR TREATING A SUBJECT AFFLICTED WITH INTESTINAL MALABSORPTION SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION 2001-11-29 US claimed
US-5997915-A NATURAL ISOMERS OF TETRAHYDROFOLIC ACID DERIVATIVES SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) 1999-12-07 US claimed
EP-0877563-A4 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES UNIV SOUTH ALABAMA (US) 1999-06-09 EP claimed
EP-0877563-A1 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES South Alabama Medical Science Foundation (US) 1998-11-18 EP claimed
WO-1997027764-A1 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) 1997-08-07 WO claimed
JP-11116482-A None JP disclosed
EP-2773355-B1 METHODS, FORMULATIONS, AND KITS FOR RAPIDLY REPLETING FOLATE LEVELS IN WOMEN SOUTH ALABAMA MEDICAL SCIENCE FOUND (US) 2022-06-08 EP disclosed
US-10357496-B2 Methods, formulations, and kits for rapidly repleting folate levels in women SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) 2019-07-23 US disclosed
US-9895328-B2 Calcium formate as a supplement to prevent neural tube defects BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2018-02-20 US disclosed
US-20160193164-A1 CALCIUM FORMATE AS A SUPPLEMENT TO PREVENT NEURAL TUBE DEFECTS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2016-07-07 US disclosed
US-5997915-A NATURAL ISOMERS OF TETRAHYDROFOLIC ACID DERIVATIVES SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) 1999-12-07 US disclosed
EP-0877563-A4 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES UNIV SOUTH ALABAMA (US) 1999-06-09 EP disclosed
JP-H11116482-A USAGE OF TETRAHYDROFOLATE OF NATURAL STEROISOMERIC FORM IN PRODUCTION OF AGENT SUITABLE FOR EXERTING INFLUENCE ON HOMOCYSTENINE-LEVEL, ESPECIALLY SUITABLE FOR ASSISTING REMETHYLATION OF HOMOCYSTENINE EPROVA AG 1999-04-27 JP disclosed
EP-0877563-A1 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES South Alabama Medical Science Foundation (US) 1998-11-18 EP disclosed
WO-1997027764-A1 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) 1997-08-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160193164-A1 CALCIUM FORMATE AS A SUPPLEMENT TO PREVENT NEURAL TUBE DEFECTS SLC19A1, FOLR2, SLC46A1 SOST 1449/4885GART 180/4885FPGS 18/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.