Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | C5 | P01031 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KIF11 | P52732 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | CDC25C | P30307 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836963 | 0.79 | KIF11 (0.68) | MAPTKIF11 | |
| SCHEMBL550449 | 0.78 | CHUK (0.60) | PTGS2MEN1MAPTKMT2AABCC4 | |
| SCHEMBL29453525 | 0.78 | CHUK (0.64) | PTGS2MEN1MAPTKMT2AABCC4 | |
| SCHEMBL607827 | 0.78 | CHUK (0.64) | PTGS2MEN1MAPTKMT2AABCC4 | |
| SCHEMBL2760335 | 0.77 | KIF11 (0.64) | PTGS2MEN1MAPTKMT2AABCC4 | |
| SCHEMBL18212083 | 0.74 | CHUK (0.53) | PTGS2MEN1MAPTKMT2AABCC4 | |
| SCHEMBL30180971 | 0.74 | PTGS2 (0.54) | PTGS2MEN1MAPTKMT2AABCC4 | |
| SCHEMBL2141394 | 0.73 | PARP1 (0.61) | PTGS2MEN1MAPTKMT2AABCC4 | |
| SCHEMBL23201853 | 0.73 | PTGS2 (0.50) | PTGS2MEN1MAPTKMT2AABCC4 | |
| SCHEMBL8004981 | 0.73 | KIF11 (0.65) | PTGS2MEN1MAPTKMT2AABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5028603-A | Platelet-Activating Factor Antagonist; Useful In Treatment Of Inflammatory Diseases, Allergic Diseases, Asthma, Respiratory System Disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-07-02 | — | — | US | disclosed |
| EP-0316456-A1 | ESTER-SUBSTITUTED THIENOTRIAZOLODIAZEPINE COMPOUNDS AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-05-24 | — | — | EP | disclosed |