Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 7/20 | 0.90 |
| ▸ | KDM2A | Q9Y2K7 | 7/20 | 0.90 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.90 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.90 |
| ▸ | KDM5C | P41229 | 4/20 | 0.90 |
| ▸ | KDM6B | O15054 | 2/20 | 0.90 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.55 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.50 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.45 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinylacetone SCHEMBL503918 | 0.95 | PHF8 (1.00) | PHF8KDM2AEGLN1KDM4EKDM5C | |
| SCHEMBL17024369 | 0.87 | PHF8 (0.65) | PHF8KDM2AEGLN1KDM4EKDM5C | |
| SCHEMBL15060527 | 0.84 | PHF8 (0.64) | PHF8KDM2AEGLN1KDM4EKDM5C | |
| SCHEMBL61062 | 0.84 | KDM4E (0.78) | PHF8KDM2AEGLN1KDM4EKDM5C | |
| SCHEMBL4098641 | 0.84 | PHF8 (0.68) | PHF8KDM2AEGLN1KDM4EKDM5C | |
| Succinylacetone SCHEMBL29120445 | 0.82 | PHF8 (0.75) | PHF8KDM2AEGLN1KDM4EKDM5C | |
| SCHEMBL18342669 | 0.81 | PHF8 (0.59) | PHF8KDM2AEGLN1KDM4EKDM5C | |
| SCHEMBL28977856 | 0.81 | EGLN1 (0.59) | PHF8KDM2AEGLN1KDM4EKDM5C | |
| SCHEMBL1774230 | 0.81 | EGLN1 (0.59) | PHF8KDM2AEGLN1KDM4EKDM5C | |
| SCHEMBL10936077 | 0.81 | KDM4E (0.55) | PHF8KDM2AEGLN1KDM4EKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991004734-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 4,6-TIOXOHEPTANOIC ACID OR ITS DERIVATIVES | CETUS CORPORATION (US) | 1991-04-18 | — | — | WO | disclosed |
| WO-1990000049-A2 | IMMUNOSUPPRESSIVE ANALOGUES AND DERIVATIVES OF SUCCINYLACETONE | CETUS CORPORATION (US) | 1990-01-11 | — | — | WO | disclosed |