Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL983980 | 1.00 | HDAC4 (0.42) | HDAC4SMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL12922379 | 1.00 | HDAC4 (0.42) | HDAC4SMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL12922380 | 0.91 | HDAC4 (0.42) | HDAC4SMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL983365 | 0.91 | HDAC4 (0.42) | HDAC4SMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL983366 | 0.91 | HDAC4 (0.42) | HDAC4SMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL12948587 | 0.79 | HDAC4 (0.36) | HDAC4SMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL5643619 | 0.78 | ALDH1A1 (0.37) | HDAC4SMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL983451 | 0.72 | HDAC4 (0.49) | HDAC4MEN1KMT2AGAA | |
| SCHEMBL4555828 | 0.71 | HDAC4 (0.50) | HDAC4KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19469572 | 0.69 | HDAC4 (0.65) | HDAC4MEN1KMT2ATDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960351-B1 | PROPIONAMIDE COMPOUNDS AS ANTIINFLAMMATORY AGENTS | HOFFMANN LA ROCHE (CH) | 2013-06-19 | — | — | EP | disclosed |
| US-7868031-B2 | Propionamide compounds as antiinflammatory agents | ROCHE PALO ALTO LLC (US) | 2011-01-11 | — | — | US | disclosed |
| EP-1963287-A1 | GLUCOCORTICOID RECEPTOR MODULATORS AS ANTIINFLAMMATORY AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-03 | — | — | EP | disclosed |
| EP-1960351-A1 | PROPIONAMIDE COMPOUNDS AS ANTIINFLAMMATORY AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| US-7348322-B2 | Glucocorticoid receptor modulators as antiinflammatory agents | ROCHE PALO ALTO LLC (US) | 2008-03-25 | — | — | US | disclosed |
| US-20070135500-A1 | Propionamide compounds as antiinflammatory agents | ROCHE PALO ALTO LLC | 2007-06-14 | — | — | US | disclosed |
| US-20070135427-A1 | Glucocorticoid receptor modulators as antiinflammatory agents | ROCHE PALO ALTO LLC | 2007-06-14 | — | — | US | disclosed |
| WO-2007065821-A1 | PROPIONAMIDE COMPOUNDS AS ANTIINFLAMMATORY AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007065828-A1 | GLUCOCORTICOID RECEPTOR MODULATORS AS ANTIINFLAMMATORY AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135500-A1 | Propionamide compounds as antiinflammatory agents | PTGS1, PTGER1, PTGES3 | HDAC4 1566/4885SMN1; SMN2 3256/4885KDM4E 3457/4885 |
| US-20070135427-A1 | Glucocorticoid receptor modulators as antiinflammatory agents | NR3C1, MC2R, NR3C2 | HDAC4 1263/4885SMN1; SMN2 4746/4885KDM4E 3688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.