Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 10/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9840610 | 0.88 | TSHR (0.44) | TSHRITGB3ITGA2BTGM2HRH2 | |
| SCHEMBL2585311 | 0.85 | P2RY12 (0.50) | TSHRITGB3ITGA2BP2RY12 | |
| SCHEMBL2585308 | 0.85 | P2RY12 (0.50) | TSHRITGB3ITGA2BP2RY12 | |
| SCHEMBL9840764 | 0.80 | TGM2 (0.47) | TGM2P2RY12KMT2A | |
| SCHEMBL5891360 | 0.80 | CALCRL (0.43) | TSHRITGB3ITGA2BHRH2HRH1 | |
| SCHEMBL6100308 | 0.80 | PREP (0.52) | TSHRITGB3ITGA2B | |
| SCHEMBL18016716 | 0.79 | TSHR (0.44) | TSHRITGB3ITGA2BHRH2HRH1 | |
| SCHEMBL9840695 | 0.79 | BCHE (0.51) | ITGB3ITGA2BHRH2HRH1P2RY12 | |
| SCHEMBL6809194 | 0.78 | TSHR (0.41) | TSHRITGB3ITGA2BHRH2HRH1 | |
| SCHEMBL23326162 | 0.77 | ITGB3 (0.48) | TSHRITGB3ITGA2BHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990614-A | N-heterocyclic amides | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-02-05 | — | — | US | disclosed |
| EP-0311517-A2 | Amide compound having glutamate receptor inhibiting activity | Takeda Chemical Industries, Ltd. (JP) | 1989-04-12 | — | — | EP | disclosed |