SCHEMBL984068

SCHEMBL984068

Cc1c(Cl)cc(C(=O)Cl)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.39
TSHR P16473 1/20 0.38
ALDH1A1 P00352 2/20 0.36
TPMT P51580 3/20 0.34
KDM4E B2RXH2 1/20 0.34
GAA P10253 1/20 0.34
GPR35 Q9HC97 1/20 0.33
HPGD P15428 1/20 0.33
MAPT P10636 1/20 0.33
SRD5A2 P31213 1/20 0.33
CHRNA1 P02708 1/20 0.33
CHRNG P07510 1/20 0.33
CHRNB1 P11230 1/20 0.33
CHRNB2 P17787 1/20 0.33
SLC6A2 P23975 1/20 0.33
CHRNB4 P30926 1/20 0.33
SLC6A4 P31645 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNA4 P43681 1/20 0.33
SLC6A3 Q01959 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22490311 0.89 TTR (0.35) TTRTSHRALDH1A1TPMTKDM4E
SCHEMBL22468542 0.85 TPMT (0.34) TTRTSHRALDH1A1TPMTKDM4E
SCHEMBL10900855 0.80 CA5A (0.48) TTRTSHRALDH1A1TPMTKDM4E
SCHEMBL1573147 0.80 TTR (0.62) TTRTSHRALDH1A1TPMTKDM4E
SCHEMBL983196 0.79 HPGD (0.46) TTRTSHRALDH1A1TPMTHPGD
SCHEMBL10921198 0.79 TTR (0.48) TTRTSHRALDH1A1TPMTKDM4E
SCHEMBL11760787 0.79 CA1 (0.41)
SCHEMBL1003805 0.78 LMNA (0.49) TTRTSHRALDH1A1KDM4EGAA
SCHEMBL985500 0.77 GAA (0.36) TSHRALDH1A1TPMTKDM4EGAA
SCHEMBL4903616 0.77 TTR (0.65) TTRTSHRALDH1A1HPGDESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109810016-B Enantiomer mixture and preparation method and application thereof 大连凯飞化学股份有限公司 2021-11-23 CN claimed
WO-2001083420-A2 METHOD OF MAKING SUBSTITUTED DIHALO AROMATIC ACID CHLORIDES OCCIDENTAL CHEMICAL CORPORATION (US) 2001-11-08 WO claimed
US-6201152-B1 HEATING MIXTURE OF METHYL-3,5-DICHLORO-4-METHYLBENZOATE AND ALPHA,ALPHA,ALPHA-TRICHLOROMETHYLBENZENE IN PRESENCE OF AMMONIUM MOLYBDATE CATALYST OCCIDENTAL CHEMICAL CORPORATION 2001-03-13 US claimed
US-5969200-A CHLORINATING PARA-TOLUOYL CHLORIDE IN PRESENCE OF CHLORINE GAS AND ALUMINUM CHLORIDE OR ANTIMONY CHLORIDE CATALYST, DISTILLING MIXTURE PRODUCED TO RECOVER 3,5-DICHLORO-4-METHYLBENZOYL CHLORIDE ROHM AND HAAS COMPANY (US) 1999-10-19 US claimed
EP-0816328-A2 Process for the manufacture of acetonylbenzamides ROHM AND HAAS COMPANY (US) 1998-01-07 EP claimed
JP-6192196-A None JP disclosed
CN-116947679-B Bisamide compound containing sevoflurane isopropyl, and preparation method and application thereof 浙江宇龙药业有限公司 2025-04-29 CN disclosed
CN-118561708-A Benzoyl bacteria method for synthesizing amine 湖北晟康化工有限公司 2024-08-30 CN disclosed
CN-116947679-A Bisamide compound containing sevoflurane isopropyl, and preparation method and application thereof 浙江宇龙药业有限公司 2023-10-27 CN disclosed
CN-115925576-B Bisamide compound containing sevoflurane isopropyl, and preparation method and application thereof 浙江宇龙药业有限公司 2023-08-08 CN disclosed
CN-115925576-A Heptafluoroisopropyl-containing bisamide compound and preparation method and application thereof 浙江宇龙药业有限公司 2023-04-07 CN disclosed
CN-109810016-B Enantiomer mixture and preparation method and application thereof 大连凯飞化学股份有限公司 2021-11-23 CN disclosed
US-5945565-A SYNTHESIS OF 4-AMINO-3-CHLORO-5-(METHOXYIMINOMETHYL)BENZOYL CHLORIDE STARTING WITH THE CONVERSION OF 5-METHYL-4-NITRO-BENZOIC ACID TO 4-NITRO-5-(METHOXYIMINOMETHYL)-BENZOIC ACID, METHYL ESTER ROHM AND HAAS COMPANY (US) 1999-08-31 US disclosed
US-5874466-A REACTING AMINE AND ACYL CHLORIDE, HYDROGENOLYSIS ROHM AND HAAS COMPANY (US) 1999-02-23 US disclosed
EP-0816330-A1 N-acetonylbenzamide fungicides ROHM AND HAAS COMPANY (US) 1998-01-07 EP disclosed
EP-0816328-A2 Process for the manufacture of acetonylbenzamides ROHM AND HAAS COMPANY (US) 1998-01-07 EP disclosed
EP-0600629-B1 N-acetonylbenzamides and their use as fungicides ROHM & HAAS (US) 1996-05-08 EP disclosed
JP-H06192196-A N-ACETONYLBENZAMIDE AND FUNGICIDAL COMPOSITION CONTAINING THE SAME ROHM & HAAS CO 1994-07-12 JP disclosed
EP-0600629-A1 N-acetonylbenzamides and their use as fungicides ROHM AND HAAS COMPANY (US) 1994-06-08 EP disclosed
US-5304572-A N-acetonylbenzamides and their use as fungicides ROHM AND HAAS COMPANY (US) 1994-04-19 US disclosed