Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 4/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9842117 | 0.94 | OPRD1 (0.36) | OPRD1OPRM1DPP8CACNA1BCACNA2D1 | |
| SCHEMBL9842315 | 0.90 | OPRD1 (0.41) | OPRD1OPRM1OPRK1KMT2ASLC6A9 | |
| SCHEMBL9841934 | 0.84 | OPRD1 (0.42) | OPRD1OPRM1OPRK1CACNA1BCACNA2D1 | |
| SCHEMBL9842205 | 0.84 | OPRD1 (0.43) | OPRD1OPRM1OPRK1MEN1KMT2A | |
| SCHEMBL25918370 | 0.74 | SLC6A2 (0.38) | OPRD1OPRM1CYP2D6 | |
| SCHEMBL9842263 | 0.72 | SLC6A4 (0.40) | CYP2D6 | |
| SCHEMBL21831856 | 0.71 | SIGMAR1 (0.39) | OPRD1OPRM1OPRK1CYP2D6 | |
| SCHEMBL21831136 | 0.71 | SIGMAR1 (0.42) | OPRD1OPRM1OPRK1CYP2D6 | |
| SCHEMBL21831108 | 0.71 | SIGMAR1 (0.39) | OPRD1OPRM1OPRK1CYP2D6 | |
| SCHEMBL21831106 | 0.71 | SIGMAR1 (0.39) | OPRD1OPRM1OPRK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0461264-A1 | ETHYNYLPHENYL DERIVATIVE, PRODUCTION THEREOF, AND REMEDY FOR DISEASES OF CIRCULATORY ORGANS CONTAINING THE SAME AS ACTIVE INGREDIENT | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1991-12-18 | — | — | EP | disclosed |