Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL9844312 | 0.91 | ALDH1A1 (0.34) | OPRD1LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL123770 | 0.88 | TRPV1 (0.46) | TRPV1CNR1CNR2LMNAALDH1A1 | |
| Acetic Acid SCHEMBL9844375 | 0.87 | TRPV1 (0.43) | TRPV1CNR1CNR2LMNAALDH1A1 | |
| Phosphoric Acid SCHEMBL9844239 | 0.83 | TRPV1 (0.42) | TRPV1CNR1CNR2LMNAALDH1A1 | |
| Lactic Acid SCHEMBL9843961 | 0.83 | MEN1 (0.40) | TRPV1CNR1CNR2LMNAALDH1A1 | |
| SCHEMBL122497 | 0.78 | TRPV1 (0.35) | TRPV1CNR1CNR2LMNAALDH1A1 | |
| Acetic Acid SCHEMBL9844165 | 0.78 | TRPV1 (0.33) | TRPV1CNR1CNR2LMNAALDH1A1 | |
| Phosphoric Acid SCHEMBL9844199 | 0.74 | ALDH1A1 (0.33) | TRPV1CNR1CNR2LMNAALDH1A1 | |
| Citric Acid SCHEMBL23644590 | 0.68 | GPR84 (0.65) | LMNAALDH1A1MAPTALOX15TSHR | |
| Palmitic Acid SCHEMBL8514384 | 0.68 | GPR84 (0.65) | LMNAALDH1A1MAPTALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0410659-A2 | Method and composition to impart improved conditioning properties to the hair | HELENE CURTIS, INC. (US) | 1991-01-30 | — | — | EP | claimed |
| US-4976956-A | Water soluble and oil soluble quaternary ammonium compounds and amidoamine | HELENE CURTIS, INC. (US) | 1990-12-11 | — | — | US | claimed |